Study participants were over the age of 18. The participants were randomly assigned to their groups. Five hundred and forty-five (545) participants received HS and 542 received IS during their operations. We included 18 trials that compared HS to IS in people undergoing surgery. The evidence is up to date to April 8th, 2016. HS might benefit people undergoing surgery by reducing the total volume of fluid required. Hypertonic salt solutions (HS) have a higher sodium concentration than isotonic salt solutions (IS). The fluids normally used during surgery have a salt balance similar to that found in blood, and are called isotonic. Sometimes large volumes of fluid are given in order to maintain adequate blood volume, but these volumes may leave people with too much fluid. People usually require fluids during surgery. Are solutions containing more salt than is normally used safe during surgery?
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